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BioDrop |
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Work plan Platform Technology Cluster Partners: CTIT, MESA, Philips Research, ULAN and industrial partners
Goal: Provide the hardware and software for a reliable digital microfluidic platform
CTIT/MESA Work plan
Task 1:
Develop a simple droplet structure, to show and evaluate droplet formation and transport, fluidic operations and sensing.
Task 2:
If the previous results are positive, a more complex digital microfluidic design, suitable for relatively simple peptide synthesis will be developed.
FEM Simulation Cluster Partners: CCLRC, IMT, MESA, CTIT and industrial partners
Goal: Provide reliable simulation results for fault-free and faulty situations of experimental droplet injection, transport, mixing and sensing device
CCLRC work plan
Task 1:
Provide independent CFD simulations of a droplet injection, transfer and sensing device using CFD-ACE+ and THOF-VOF.
Task 2:
Provide CFD modelling to support the design and optimisation of the peptide synthesizer.
IMT Bucharest work plan
Task 1:
CoventorWare simulations of the design and evaluation of simple test structures, for the study of failure modes and faults of droplet fluidic operations (injection, transport, merging).
Task 2:
Simulations for the design and evaluation of bio-fluidic droplet structures focussed on the QinetiQ droplet device. Analysis for optimisations of numerical models.
Task 3:
Responsibility on design and maintenance of BioDrop website.
Droplet Sensing & Evaluation Cluster Partners: LIRMM, ULAN, MESA, CTIT and industrial partners
Goal: Develop the scientific background and electronics for sensing the droplets and their contents for the two target applications.
LIRMM work plan
Task 1:
Determination of nominal value of the capacitance and expected relative variation in presence of a droplet.
Task 2:
Reconfiguration of the test system for conductance measurements.
ULAN work plan
Task 1:
The off-line testing for the Micro Electrode Array (MEA).
Task 2:
The on-line testing for the Micro Electrode Array.
Task 3:
The investigation on cell delivery and detection.
Biochemical Application Cluster Partners: QinetiQ, MultiSynTech, Pepscan Systems, ULAN, MESA and CTIT
Goal: Provide information on the market application requirements, suggested biochemical flow and problem solution, manufacturability/packaging. The effort will be continuous over the whole duration of BioDrop, but before the design of the application is started, the major application requirements flow and market must be clear.
QinetiQ, the main user on the bio-cell analysis application of BioDrop, will provide MEAs, the cell and buffer fluidics, and bring in extensive experience on cell analysis processing and knowledge of the market. Also use can be made of evaluation equipment. If droplet transport can be incorporated successfully, it can be part of a new product thereby taking care of sustainability. Pepscan Systems and MultiSynTech are the focus of the droplet peptide synthesis research in BioDrop. They bring in knowledge of diseases related to peptides used for drugs, and have a long expertise in peptide synthesis and detailed knowledge on (software-controlled) peptide production flow at macro scale. Beside manpower, also bio agents will be provided and use can be made of peptide purity measurement equipment. In case of success, MultiSynTech could start a new line for peptide synthesis, thereby guaranteeing sustainability. Philips Research is interested in our droplet delivery approach, and will provide free 90nm CMOS substrates. |
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